TY - JOUR AU - Lin, Ju-Li AU - Lin, Jian-Xian AU - Zheng, Chao-Hui AU - Xie, Jian-Wei AU - Wang, Jia-Bin AU - Lu, Jun AU - Chen, Qi-Yue AU - Cao, Long-Long AU - Lin, Mi AU - Li, Ping AU - Huang, Chang-Ming PY - 2020/02/28 Y2 - 2024/03/29 TI - Long-term proton pump inhibitor use and the incidence of gastric cancer: A systematic review and meta-analysis JF - Journal of Gastric Surgery JA - J Gastric Surg VL - 2 IS - 1 SE - Systematic review and Meta-analysis DO - 10.36159/jgs.v2i1.17 UR - https://www.journalofgastricsurgery.com/index.php/JGS/article/view/17 SP - 1-11 AB - <p><strong>Background: </strong>There are controverted whether the long-term use of proton pump inhibitors (PPI) will increase the risk of gastric cancer. We performed a meta-analysis to assess the risk of gastric cancer in PPI users compared with non-PPI users.</p><p><strong>Methods: </strong>The main inclusion criteria were original studies reporting the incidence of gastric cancer in PPI users compared with non-PPI users. Key outcomes were the risk ratios (RR) for gastric cancer in association with PPI users or non-PPI users.</p><p><strong>Results: </strong>We analyzed data from 8 studies, comprising more than 927,684 patients. The risk of gastric cancer in PPI users was significantly higher than in non-PPI users [RR= 2.10, 95% CI (1.17-3.97)]. The risk of gastric cancer was similar between the 2 groups when the duration was ≤1 year [RR= 2.18, 95% CI (0.66-7.11)]. While the risk of gastric cancer for PPI users was higher than in non-PPI users when the duration was between 1-3 years, ≥1 year, ≥3 years and ≥5 years. The risk of non-cardiac gastric cancer for PPI users was higher than for non-PPI users [RR= 2.66, 95% CI (1.66 -4.27)], and the risk of non-cardiac gastric cancer for PPI users was higher than for non-PPI users when the duration ≥1 year [RR= 1.99, 95% CI (1.03-3.83)], but the risk for cardiac gastric cancer was similar between the 2 groups [RR= 1.86, 95% CI (0.71-4.89)].</p><p><strong>Conclusions: </strong>We found the long-term use of PPI (duration ≥1 year) was significantly associated with a higher risk of non-cardiac gastric cancer.</p> ER -